‘How’d you get her pregnant at 80?’

Oh, baby.

Robert De Niro was able to laugh off 2024 Golden Globes host Jo Koy’s joke about the thespian’s unexpectedly growing family during his opening monologue.

De Niro, 80, welcomed his seventh child, daughter Gia, with his girlfriend, Tiffany Chen, 45, in April.

During Sunday’s show, Koy, who claimed to be a massive fan of the “Goodfellas” star, looked his idol’s way and said, “This guy’s amazing decade after decade. He just kills it every single time. I don’t know how you do it.

“Man. I swear to God, your last performance is going to be your greatest performance ever,” Koy geared up for the punchline. “How’d you get her pregnant at 80?

“CGI?” Koy asked De Niro, who chuckled from his seat.

The Post has contacted reps for De Niro for comment.

Fans took to De Niro’s defense on X, the platform previously known as Twitter.

“Where’s Will Smith when you need him?” one viewer wrote, referencing the infamous 2022 Oscars slap.

“Such tasteless jokes,” another said.

“Jo Koy’s not very funny. I changed the channel,” a third added.

De Niro was up for one nomination for Best Supporting Actor for his role in “Killers of the Flower Moon” on Sunday, losing to Robert Downey Jr. for “Oppenheimer.” However, he has won two Golden Globes previously.

In October, he told the Guardian that Chen was doing the “heavy lifting” in raising their daughter.

“It doesn’t get easier. It is what it is. It’s OK,” he said at the time.

“I don’t do the heavy lifting. I’m there, I support my girlfriend. But she does the work. And we have help, which is so important.”

He continued: “With a baby, it’s different [than] with my 11-year-old. My adult children. My grandchildren. It’s all different.”

When asked if he’s enjoying fatherhood, he replied: “Of course I do. [I am happy with] all of it.”

De Niro also shares kids Drena, 51, and Raphael, 46, with his first wife, Diahnne Abbott; 27-year-old twins Julian and Aaron with model and actress Toukie Smith; and son Elliot, 25, and daughter Helen, 12, with his second wife, Grace Hightower.